Formulation and Evaluation of Brimonidine Maleate Nanolipid in Situ Gel

Abstract

The main objective of present research work was aimed to formulate and evaluate the nano lipid-based drug delivery system by incorporating a brimonidine maleate drug for ocular therapy. The patient can be improved by preparing nano lipid in situ gel as a vehicle by reducing the frequency of administration and increasing the ocular bioavailability. Nanolipids were prepared by film hydration technique and then prepared nanolipids were incorporated into insitu gel by using various polymers like Carbopol 940 and HPMC K15M with different concentration. The various formulations prepared showed excellent and effective results for visual appearance, pH, and gellation study. It was further observed that formulations had entrapment efficiency within the range of 67.20% to 97.3% for brimonidine maleate loaded insitu gel formulations. F1 entrapment efficiency was found to be 97.3% and shown maximum when compared with other formulations. From the drug release data, it was found that F1 (99.0%) shows maximum drug release compare to other formulations.