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\begin{document}


\def\RunningAuthor{Ahsana Asif and Subramanian E M G}
\firstPage{6727}
\articleType{Review Article}
\receivedDate{20 Jun 2020}
\acceptedDate{28 Jul 2020}
\revisedDate{25 Jul 2020}
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\title{\textbf{Obturation Techniques in Primary Teeth using Endoflas as Obturation Material {\textendash} A Systematic Review}}
\author{Ahsana~Asif\textsuperscript{*}, 
            Subramanian~E~M~G~\\[5pt]{Department of Pediatric and Preventive Dentistry, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India}}

\begin{abstract}
A pulpectomy is the treatment of choice for pulpally involved primary teeth. Pulp therapy prevents the premature loss of primary teeth which could result in loss of arch length, an altered pathway of the eruption of primary teeth, development of aberrant habits. It also restores the dentition to a functional state. Endoflas is a newer obturation material which has a proven clinical success rate. There are various obturation techniques available in the literature. The systematic review aimed to extract and systematically identify the existing literature, which compares different obturation techniques used in the root canal treatment of primary teeth using endoflas as obturation material. The search was done using the MeSH terms and keyword search in the electronic databases, including PubMed, Cochrane, LILAC, Sigle, Science Direct and Google scholar. A total of 13 articles were chosen after the initial screening of the title. Then based on the inclusion and exclusion criteria and the availability of the full texts, a total of 3 articles were included. This systematic review concludes that there is a need to update the existing literature to find out the beat ideal obturation technique which can provide void-free and ideal obturation of the root canal of the primary teeth using Endoflas.
\end{abstract}\def\keywordstitle{Keywords}

\begin{keywords}Obturation Techniques,\newline Primary teeth,\newline Endoflas,\newline Systematic review
\end{keywords}
\twocolumn[ \maketitle {\printKwdAbsBox}]
\makeatletter{\raggedright\textsuperscript{*}Corresponding Author\par Name:\ Ahsana~Asif~\\ Phone:\ 9176543653~\\  Email:\ ahsanaasif93@gmail.com
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\section{Introduction}
Dental caries, a most common infectious disease, affects the oral health of humans despite numerous advances in the field of preventive dentistry \unskip~\citep{917471:20624811}. Primary teeth are usually more prone to dental caries. This could be due to variations in the morphological characteristics and improper oral hygiene practices which lead to early involvement of the pulp \unskip~\citep{917471:20624812}. Primary teeth are essential not only for the normal development of jawbone and musculature but also for the guidance of eruption of succedaneous permanent teeth and phonation, mastication and esthetics. Early and premature loss of primary teeth can lead to alteration in the eruption pathway of permanent teeth, development of aberrant habits, altered phonation, etc. Hence, endodontic treatment and preservation of primary teeth are essential \unskip~\citep{917471:20624815,917471:20624818}. A pulpectomy is considered to be the choice of treatment for the tooth in which the pulp tissue is irreversibly affected \unskip~\citep{917471:20624821}. According to AAPD guidelines, the steps in pulpectomy should include debridement, shaping of the canals with hand and/or rotary files, irrigation with irritants like sodium hypochlorite and/or chlorhexidine, drying of the canals and obturation/filling of the canals with a resorbable material. Finally, a coronal restoration is given to seal the tooth from microleakage \unskip~\citep{917471:20624825}. Thorough aseptic preparation and hermetic seal of the root canal system is essential for the clinical success of the pulpectomy \unskip~\citep{917471:20624831}. This is achieved by thorough chemo-mechanical preparation and obturation with an ideal obturating material with minimal voids in the root canal system. The success is also influenced by appropriate case selection, mixing of the obturation material and usage of proper technique for obturation \unskip~\citep{917471:20624812,917471:20624822}. 

The prime objectives of the root canal fillings are to adapt and fill the root canal obturation material to the entire length of the root canal without extrusion of the material and to avoid the creation of voids \unskip~\citep{917471:20624826}. The three-dimensional fluid-tight seal of the root canal system hinders the microleakage and cuts off the nutrient supply to any surviving microorganism. 

The 3D seal is also necessary to prevent recurrence of infection \unskip~\citep{917471:20624834,917471:20624819}. To achieve good obturation, various obturation techniques have been proposed \unskip~\citep{917471:20624833,917471:20624812,917471:20624824}. 

Different authors have compared different obturation techniques, and the outcome of their studies vary with each other, and there is no standard gold technique for the obturation of primary teeth. Hence, the main aim of this systematic review is to find out the best obturation technique among the various obturation techniques that are being used \unskip~\citep{917471:20624822,917471:20624834,917471:20624819}.
    
\section{Materials and Methods}
This review was done under the guidelines given by the Cochrane Handbook of Systematic Reviews.

\textbf{Structured Question}

What is the ideal obturation technique following the root canal treatment of the primary teeth using Endoflas as obturation material?

\textbf{PICO Analysis}


  
  \begin{enumerate}
  \item \relax Population: primary teeth undergoing pulpectomy 
  \item \relax Intervention: Obturation using any technique and using Endoflas as obturation material
  \item \relax Outcome: Quality of obturation 
  \end{enumerate}
  \textbf{Inclusion criteria}

Studies were selected using the following inclusion criteria.


  
  \begin{enumerate}
  \item \relax All studies reporting obturation using Endoflas as obturation material and any technique
  \item \relax All studies reporting the quality of obturation in primary molar teeth
  \item \relax Studies published in the English language
  \item \relax In vivo studies
  \end{enumerate}
  \textbf{Exclusion criteria}

Studies were excluded based on the following exclusion criteria.


  
  \begin{enumerate}
  \item \relax Studies for permanent teeth
  \item \relax Studies which uses obturation material other than Endoflas
  \item \relax Animal studies
  \item \relax In vitro studies
  \item \relax Reviews, case reports, abstracts, letters to editors
  \end{enumerate}
  \textbf{Search method }

A literature search was done to identify the studies to be included in the following databases

1. PubMed (Till September 2018)

2. The Cochrane Central Register of Clinical Trials (Till September 2018)

3. Science Direct

4. LILACS

5. SIGLE

All the MeSH headings, word variants and text words for ``primary teeth'', ``pulpectomy'', ``obturation techniques'' which were combined using Boolean operator for the search. Only those articles in the English language and those with human studies were only included. Bibliography of the included studies was also checked for any additional studies which were not included in the electronic search databases (Chart~\ref{f-18a16cdfd956}).

\textbf{Search Strategy}

\textbf{PubMed Strategy}

Advanced search of PubMed search engine using the following keywords was used:

 ((((((((primary teeth) OR primary tooth) OR deciduous teeth) OR deciduous tooth) OR milk teeth) OR milk tooth)) AND ((((((((((pulp therapy) OR pulpectomy) OR endodontic treatment) OR endodontic therapy) OR root canal treatment) OR root canal therapy) OR obturation) OR root canal filling) OR obturation technique) OR endoflas)) AND (((((obturation quality) OR quality of obturation) OR under obturation) OR over obturation) OR optimal obturation)

This search yielded 82 studies. Figure~\ref{f-10e7539c6d0a} shows the PubMed search strategy.

\textbf{Selection of studies}

One author carried out the search strategy for the individual databases. All the titles obtained were scanned and evaluated independently by two authors to identify the relevant studies. The studies which were duplicated in different databases were excluded. In case of any disagreement between the two authors, the final decision was made after the discussion of the two authors. Abstracts of the studies were evaluated when complete information regarding the study sample, and groups included were not mentioned in the title. The evaluation of the abstract was carried out independently by the same two authors to identify the studies that have to be included for final evaluation based on the inclusion and exclusion criteria. Full-text articles were evaluated if the information available in the abstract regarding the groups compared was not sufficient. The reference list of all the full-text articles was evaluated to identify any studies which were not included in the electronic search.

\textbf{Data synthesis}

\textbf{Data extraction from the selected studies}

Data were extracted independently by the two authors using a data extraction form. The data extracted were


  
  \begin{enumerate}
  \item \relax Name of the author and year of publication
  \item \relax Study design 
  \item \relax Population group
  \item \relax Total sample size and age group
  \item \relax Obturation technique used
  \item \relax Criteria used to assess the quality of obturation. 
  \end{enumerate}
  \textbf{Quality Assessment}

The final studies that were included after the discussion between the two authors were subjected to quality assessment following the guidelines given by the Cochrane Handbook of a systematic review 


  
  \begin{enumerate}
  \item \relax Random sequence generation
  \item \relax Allocation concealment
  \item \relax Blinding of participants and personnel
  \item \relax Blinding of outcome assessment
  \item \relax Free of incomplete outcome data assessment
  \item \relax Selective reporting
  \item \relax Other bias
  \end{enumerate}
  The final risk of bias of individual study was determined as low risk if all the studies showed a low risk for the individual parameters. In case of high or unclear risk for anyone or two parameters, then study was considered to be at moderate risk. In case of high risk in more than two parameters, the included study was considered to have a high risk of bias. 


\begin{table*}[!htbp]
\caption{\boldmath {Characteristics of included studies} }
\label{tw-ce6e206a8c1e}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.19615\linewidth-2\tabcolsep}p{\dimexpr.16595\linewidth-2\tabcolsep}p{\dimexpr.15755\linewidth-2\tabcolsep}p{\dimexpr.15345\linewidth-2\tabcolsep}p{\dimexpr.16315\linewidth-2\tabcolsep}p{\dimexpr.16375\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Author and year & \cAlignHack Study population & \cAlignHack Sample size  & \cAlignHack Teeth & \cAlignHack Obturation technique used & \cAlignHack Outcome assessment\\
\tblmidrule 
\unskip~\citep{917471:20624833} &
  41 children (4-9 years)  &
  60 primary teeth;  \mbox{}\protect\newline 20 Teeth in each group  &
  32 mandibular 1\ensuremath{^{st}} molar  \mbox{}\protect\newline 28 mandibular 2\ensuremath{^{nd}} molar  &
  Disposable syringe  \mbox{}\protect\newline Lentulospiral  \mbox{}\protect\newline Past inject  &
  Level of canal obturation  \mbox{}\protect\newline Voids \\
\unskip~\citep{917471:20624829} &
  38 children \mbox{}\protect\newline (4-9 years) &
  45 teeth; \mbox{}\protect\newline 15 teeth in each group &
  45 mandibular molar &
  Endodontic pluggers \mbox{}\protect\newline Lentulospirals Navi Tips  &
  Level of canal obturation \mbox{}\protect\newline Voids \\
\unskip~\citep{917471:20624836} &
  60 children \mbox{}\protect\newline (4-8 years) &
  60 teeth; \mbox{}\protect\newline 30 teeth in each group &
  7 and 15 maxillary 1\ensuremath{^{st}} and 2\ensuremath{^{nd}} molar respectively \mbox{}\protect\newline 17 and 21 mandibular 1\ensuremath{^{st}} and 2\ensuremath{^{nd}} molar respectively  &
  Handheld lentulo spiral \mbox{}\protect\newline Modified disposable syringe &
  Level of canal obturation \mbox{}\protect\newline Voids\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {General information on the results of the included studies} }
\label{tw-7e04085f13da}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.2172142857142857\linewidth-2\tabcolsep}p{\dimexpr.2548142857142858\linewidth-2\tabcolsep}p{\dimexpr.13041428571428568\linewidth-2\tabcolsep}p{\dimexpr.09581428571428573\linewidth-2\tabcolsep}p{\dimexpr.10431428571428572\linewidth-2\tabcolsep}p{\dimexpr.10181428571428569\linewidth-2\tabcolsep}p{\dimexpr.09561428571428571\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Author and year & \cAlignHack Obturation technique used & \multicolumn{3}{p{\dimexpr(.3305428571428571\linewidth-2\tabcolsep)}}{\cAlignHack Level of canal obturation} & \multicolumn{2}{p{\dimexpr(.1974285714285714\linewidth-2\tabcolsep)}}{\cAlignHack voids}\\
\rowcolor{kwdboxcolor}\cAlignHack  & \cAlignHack  & \cAlignHack Underfill & \cAlignHack Overfill & \cAlignHack Optimal fill & \cAlignHack present & \cAlignHack absent\\
\tblmidrule 
\multicolumn{1}{p{\dimexpr(.2172142857142857\linewidth-2\tabcolsep)}}{\multirow{2}{\linewidth}{\unskip~\citep{917471:20624833}}} &
  Disposable syringe  &
  \cAlignHack 15\%  &
  \cAlignHack 10\%  &
  \cAlignHack 8.3\%  &
  \cAlignHack 25\%  &
  \cAlignHack 8.3\% \\
 &
  Lentulospiral  &
  \cAlignHack 25\%  &
  \cAlignHack 5\% &
  \cAlignHack 3.3\% &
  \cAlignHack 13.3\% &
  \cAlignHack 20\%\\
 &
  Past inject  &
  \cAlignHack 11.7\%  &
  \cAlignHack 18.3\% &
  \cAlignHack 3.3\% &
  \cAlignHack 26.7\% &
  \cAlignHack 6.7\%\\
\multicolumn{1}{p{\dimexpr(.2172142857142857\linewidth-2\tabcolsep)}}{\multirow{3}{\linewidth}{\unskip~\citep{917471:20624829}}} &
  Endodontic pluggers &
  \cAlignHack 31.1\% &
  \cAlignHack 6.7\% &
  \cAlignHack 62.2\%  &
  \cAlignHack 31.1\% &
  \cAlignHack 68.9\%\\
 &
  Lentulospirals  &
  \cAlignHack 26.7\% &
  \cAlignHack 8.9\% &
  \cAlignHack 64.4\% &
  \cAlignHack 31.1\% &
  \cAlignHack 68.9\%\\
 &
  Navi Tips  &
  \cAlignHack 28.9\%  &
  \cAlignHack 22.2\% &
  \cAlignHack 48.9\% &
  \cAlignHack 46.7\% &
  \cAlignHack 53.3\% \\
\multicolumn{1}{p{\dimexpr(.2172142857142857\linewidth-2\tabcolsep)}}{\multirow{2}{\linewidth}{\unskip~\citep{917471:20624836}}} &
  Hand held lentulospiral &
  \cAlignHack 10\% &
  \cAlignHack 30\% &
  \cAlignHack 60\% &
  \cAlignHack 66.7\% &
  \cAlignHack 33.3\%\\
 &
  Modified disposable syringe &
  \cAlignHack 10\% &
  \cAlignHack 23.3\% &
  \cAlignHack 66.7\% &
  \cAlignHack 50\% &
  \cAlignHack 50\%\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Quality of assessment of the included studies } }
\label{tw-e12188717c82}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1635\linewidth-2\tabcolsep}p{\dimexpr.1047\linewidth-2\tabcolsep}p{\dimexpr.1015\linewidth-2\tabcolsep}p{\dimexpr.10719999999999999\linewidth-2\tabcolsep}p{\dimexpr.111\linewidth-2\tabcolsep}p{\dimexpr.1127\linewidth-2\tabcolsep}p{\dimexpr.1054\linewidth-2\tabcolsep}p{\dimexpr.09520000000000001\linewidth-2\tabcolsep}p{\dimexpr.09879999999999999\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Study  & \cAlignHack Random sequence generation & \cAlignHack Alloca-     tion concealment  & \cAlignHack Blinding of participants and personnel  & \cAlignHack Blinding of outcome assessment  & \cAlignHack Incom-      plete outcome data assessment  & \cAlignHack Selective reporting of outcome  & \cAlignHack Other sources of bias  & \cAlignHack Risk of bias \\
\tblmidrule 
\unskip~\citep{917471:20624833} &
  \cAlignHack High risk  &
  \cAlignHack Unclear risk  &
  \cAlignHack High risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Unclear risk  &
  \cAlignHack High risk \\
\unskip~\citep{917471:20624829} &
  \cAlignHack High risk  &
  \cAlignHack Unclear risk  &
  \cAlignHack High risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Unclear risk  &
  \cAlignHack High Risk \\
\unskip~\citep{917471:20624836} &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack High risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Low risk  &
  \cAlignHack Moderate risk \\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Characteristics of excluded articles} }
\label{tw-8f50cf938feb}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.4627\linewidth-2\tabcolsep}p{\dimexpr.5373\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}\cAlignHack Author and Year & \cAlignHack Reason for exclusion\\
\tblmidrule 
\unskip~\citep{917471:20624820} &
  Endoflas is not used as an obturating material.\\
\unskip~\citep{917471:20624837} &
  Endoflas is not used as an obturating material.\\
\unskip~\citep{917471:20624817} &
  In vitro study\\
\unskip~\citep{917471:20624835} &
  Retrospective study\\
\unskip~\citep{917471:20624830} &
  Endoflas is not used as an obturating material\\
\unskip~\citep{917471:20624834} &
  In vitro study using zinc oxide eugenol\\
\unskip~\citep{917471:20624812} &
  Review article\\
\unskip~\citep{917471:20624819} &
  Endoflas is not used as an obturating material.\\
\unskip~\citep{917471:20624824} &
  Endoflas is not used as an obturating material.\\
\unskip~\citep{917471:20624828} &
  Tooth type is not mentioned.\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}
Characteristics of the included studies and general information of the included studies were mentioned in Table~\ref{tw-ce6e206a8c1e} and Table~\ref{tw-7e04085f13da}, respectively.

Quality of assessment of the included studies was mentioned in Table~\ref{tw-e12188717c82}. Risk if bias was mentioned in Figure~\ref{f-0fb33a78151f} and Figure~\ref{f-22d099da1bdb}. Characteristics of the excluded studies were mentioned in Table~\ref{tw-8f50cf938feb}
    
\section{Results}
\textbf{Study Selection}

The systematic search from PubMed, Cochrane Library, Science Direct, LILACS, SIGLE and hand search revealed a total of 109 studies. On title screening, 96 articles were eliminated. After abstract screening and reviewing of full articles, three were included for the systematic review. A total of 3 articles met the inclusion criteria and were selected for the area of the intended research.


\bgroup
\fixFloatSize{images/2f4ed080-22d4-4b26-9ade-0f08d27e6f16-upicture1.png}
\begin{figure*}[!htbp]
\centering \makeatletter\IfFileExists{images/2f4ed080-22d4-4b26-9ade-0f08d27e6f16-upicture1.png}{\includegraphics{images/2f4ed080-22d4-4b26-9ade-0f08d27e6f16-upicture1.png}}{}
\makeatother 
\caption{\boldmath {Image showing the PubMed search strategy}}
\label{f-10e7539c6d0a}
\end{figure*}
\egroup

\bgroup
\fixFloatSize{images/8cf24328-d600-4709-8d3a-277b7c0b7e06-upicture3.png}
\begin{figure}[!htbp]
\centering \makeatletter\IfFileExists{images/8cf24328-d600-4709-8d3a-277b7c0b7e06-upicture3.png}{\includegraphics{images/8cf24328-d600-4709-8d3a-277b7c0b7e06-upicture3.png}}{}
\makeatother 
\caption{\boldmath {Risk of bias summary}}
\label{f-0fb33a78151f}
\end{figure}
\egroup

\bgroup
\fixFloatSize{images/044940bf-03f8-4410-95de-f97315dd0bdb-upicture4.png}
\begin{figure}[!htbp]
\centering \makeatletter\IfFileExists{images/044940bf-03f8-4410-95de-f97315dd0bdb-upicture4.png}{\includegraphics{images/044940bf-03f8-4410-95de-f97315dd0bdb-upicture4.png}}{}
\makeatother 
\caption{\boldmath {Risk of bias graph}}
\label{f-22d099da1bdb}
\end{figure}
\egroup

\bgroup
\fixFloatSize{images/1ae36e10-a09e-4104-9f91-03a5add66478-upicture2.png}
\begin{chart*}[!htbp]
\centering \makeatletter\IfFileExists{images/1ae36e10-a09e-4104-9f91-03a5add66478-upicture2.png}{\includegraphics{images/1ae36e10-a09e-4104-9f91-03a5add66478-upicture2.png}}{}
\makeatother 
\caption{\boldmath {Search Flowchart}}
\label{f-18a16cdfd956}
\end{chart*}
\egroup
\textbf{Study characteristics}

Mahima Gandhi compared the efficacy of disposable syringe, lentulo spiral, and past inject. The study was conducted in forty-one patients consisting of 13 females and 28 males between the age of 4-9. Sixty teeth indicated for single sitting pulpectomy were involved in the study. Optimally filled canals were frequently observed in Past inject Group. (18.3\%). Underfilled canals was frequently observed in Lentulospiral group. (25\%). Overfilled canals were frequently observed in Disposable Syringe Group (10\%). Significant differences(p{\textless}0.05) was observed among the three comparison groups. Lentulo spiral exhibited the highest incidence of voids of 20\%, and past injects, and pressure syringe exhibited 6.7\% and 8.3 \% respectively. \unskip~\citep{917471:20624833}. 

Jayalakshmi Pandranki compared plugger, lentulo spiral and NaviTips for delivery of Endoflas in the root canals of 45 primary molar teeth in thirty-eight children between the age group of 4-9 years of age. Pluggers (62.2\% optimal fills) and lentulo spirals (64.4\% optimal fills) showed best and acceptable results with Endoflas compared to NaviTip system (48.9\%). No significant difference was seen among the three experimental groups. Minor voids were reported with all the three groups. The frequency of voids was more in NaviTip system (46.7\%) compared to pluggers (31\%) and lentulo spirals (31.1\%), but no significant difference was found among the study groups (\textit{P} = 0.208) \unskip~\citep{917471:20624829}. 

\unskip~\cite{917471:20624836} compared two different techniques viz.; handheld lentulo spiral and disposable syringe in 60 primary mandibular and maxillary molars in sixty children between the age group of 4-8 years. Increased percentage of optimal fillings in the modified disposable syringe group (66.7\%) was seen as compared to the handheld lentulo spiral group (60\%). In contrast, the modified disposable syringe group showed a decreased number of overfilled canals when compared to the handheld lentulo spiral group. Voids were found in both the comparison groups. A significant difference was found in the apical third of the root canal (\textit{P} = 0.01) while coronal and middle thirds showed no statistical difference for voids \unskip~\citep{917471:20624836}. 
    
\section{\textbf{DISCUSSION}}
Dental caries is considered to be the most common oral health concern found among children and also in adults. To maintain the arch spaces, integrity, occlusion and normal development of jaw and musculature, it is essential to retain primary teeth in the dental arch. For a tooth which is pulpally involved with irreversible pulpitis or necrosed, pulpectomy is considered as the treatment of choice.  

Among the different obturation materials available, Endoflas is a hydrophilic material consisting of Z.O.E. (56.5\%), iodoform (40.6\%), calcium hydroxide (1.07\%), barium sulfate (1.63\%), eugenol, and pentachlorophenol. It provides a good seal with the root canals. The broad-spectrum antibacterial activity helps in disinfection of the hard to reach dentinal tubules and accessory canals \unskip~\citep{917471:20624814}. Since the resorption rate of Endoflas is similar to that of the physiological root resorption rate, the resorption is limited to the obturation material that is extruded beyond the apex extra without the resorption of the material inside the root canal \unskip~\citep{917471:20624816}. Endoflas has a high success rate when compared to that of zinc oxide eugenol \unskip~\citep{917471:20624816}. It has a clinically proven success rate of 93.3\%{\textendash}95.1\% \unskip~\citep{917471:20624821,917471:20624813,917471:20624827}. However, the success rate is lower (58\%{\textendash}76\%) when extruded beyond apex \unskip~\citep{917471:20624835,917471:20624821}. 

The present systematic review includes three studies. The outcome was assessed based on the level of canal obturation and presence/absence of voids. Coll and Sadrian criteria \unskip~\citep{917471:20624832}, Guelmann's criteria \unskip~\citep{917471:20624823} and Memarpur's scoring criteria \unskip~\citep{917471:20624824} were used to assess the level of obturation. 

The quality of assessment was done based on the Cochrane database with seven criteria of assessment to have a standardized method.  Among the three articles included in this systematic review, two articles \unskip~\citep{917471:20624833,917471:20624829} showed a high risk of bias and one article \unskip~\citep{917471:20624836} showed a moderate risk of bias. Blinding of personnel and participants was not satisfactory in all the three articles. In the study by Mahima Gandhi et al., and Pandranki et al. randomization were not adequate, and allocation concealment was not apparent. This shows the need for more high-quality studies free of any source of bias.

There are various obturation techniques available in the literature. But there are only a few clinical studies which compare the different obturation techniques for the primary teeth using Endoflas. The studies included in this systematic review compare only a few obturation techniques while there are so many techniques which can be used for obturation of primary teeth.
    
\section{Conclusion}
This systematic review concludes a lack of existing literature on the in vivo efficacy of different obturating techniques for primary teeth using Endoflas as obturating material. This research also advises updating the existing literature to find out the best obturation technique that can provide void-free and ideal obturation of the root canals of primary teeth using Endoflas.

\textbf{Ethical Clearance}

Taken from Institutional Review Board, Saveetha Dental College and Hospitals, Chennai, India (IHEC/SDC-PEDO1703/19/006)

\textbf{Funding Support}

The authors declare that they have no funding support for this study.

\textbf{Conflict of Interest}

The authors declare that they have no conflict of interest for this study.
    

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