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\def\RunningAuthor{Umamaheswara Rao T et al.}
\firstPage{323}
\articleType{Original Article}
\receivedDate{12 Nov 2020}
\acceptedDate{19 Dec 2020}
\revisedDate{13 Dec 2020}
\journalVolume{2020, 11 (SPL4)}
\journalDoi{ijrps.v11iSPL4.3798}
\copyrightYear{2020}
\def\authorCount{4}
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\def\journalTitle{International Journal of Research in Pharmaceutical Sciences}

\title{\textbf{Analysis on the evaluation of aceclofenac bilayer tablets and its formulation using FT-IT method}}
\author{Umamaheswara~Rao~T\textsuperscript{*}\textsuperscript{1},  
            Smitha~M\textsuperscript{2},  
            Maghiben~M\textsuperscript{3}, 
            Damodara~Velayudham~A\textsuperscript{4}~\\[5pt]{\textsuperscript{1}Department of Surgery, Konaseema Institute of Medical Sciences Research Foundation, Amalapuram, Andhra Pradesh, India}~\\{\textsuperscript{2}Department of OBG, Konaseema Institute of Medical Sciences Research Foundation, Amalapuram, Andhra Pradesh, India}~\\{\textsuperscript{3}Department of Radio Diagnosis, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India}~\\{\textsuperscript{4}Department of OBG, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India}}

\begin{abstract}
The detached of the current research progress a bilayer tablet of aceclofenac utilizing sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as super disintegrants for the formulation of immediate-release layer whereas polymers such as methocel K15M, Lubrizol 971P were utilized by the formulation of sustaining layer. The tablets were equipped by straight density technique. The organized tablets were estimated for pre-compressed parameters like micromeritic properties and post compressed parameters like bulk variation, aceclofenac satisfied and in-vitro dissolution studies. The in-vitro dissolution studies showed about 86.78 \% of aceclofenac release from the bilayer tablet, indicating that a preliminary burst release of aceclofenac followed by sustaining action up to 12 h by the sustained layer of the tablets. In-Vitro kinetic data revealed that all the formulations surveyed the Higuchi prototype via fickian dispersal as announcement device subsequently the preliminary rupture announcement. FT-IR studies exposed here is no communication among the drug and polymers utilized in the study. In this context, the most commonly used pain-relieving agent is aceclofenac an NSAID. In the present investigation, aceclofenac bilayer tablets were prepared to provide sustain effect for better therapeutic effect. These points of interest, clarify the requirement for the planning of changed medication conveyance framework. 
\end{abstract}\def\keywordstitle{Keywords}

\begin{keywords}Aceclofenac,\newline super disintegrants,\newline sustaining layer,\newline fickian diffusion
\end{keywords}
\twocolumn[ \maketitle {\printKwdAbsBox}]
\makeatletter{\raggedright\textsuperscript{*}Corresponding Author\par Name:\ Umamaheswara~Rao~T~\\ Phone:\ ~\\  Email:\ umamaheswararao@gmail.com 
        \par}\vspace*{-11pt}\hrulefill\par{\fontsize{12}{14}\selectfont ISSN: 0975-7538}\par% 
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        \vspace*{-2pt}{\fontsize{9.12}{10.12}\selectfont\textcopyright\ \@copyrightYear\ $|$ All rights reserved.}\par%
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        \makeatother
        
    
\section{Introduction}
Drug delivery system is intended for augmenting the remedial file of the medication and furthermore for a decrease in the results\unskip~\citep{963808:21049251}. Oral ingestion is the prevalent and most ideal course for drug conveyance on the grounds that the ease of treatment and simplicity of organization prompts a more elevated level of patient compliance\unskip~\citep{963808:21049253}. Viable oral medication conveyance may rely on variables, for example, gastric discharging measure, the gastrointestinal travel season of dose structure, drug discharge from the dose structure and site of retention of medications\unskip~\citep{963808:21049244}. Supported oral medication conveyance frameworks offer a few focal points over prompt delivery dose shapes and diminished results\unskip~\citep{963808:21049243}. A few troubles are looked in planning continued delivery frameworks for better ingestion and improved bioavailability\unskip~\citep{963808:21049245}. Medication retention from the gastrointestinal parcel is an unpredictable system and is dependent upon numerous factors\unskip~\citep{963808:21049249}. It is generally recognized that the degree of gastrointestinal lot drug assimilation is identified with contact time with the little intestinal mucosa\unskip~\citep{963808:21049248} which will adjust the pharmacokinetics and pharmacodynamics of pharmacologically dynamic moiety in a chose course of organization\unskip~\citep{963808:21049246}. Torment is generally perceived as a sign of infection\unskip~\citep{963808:21049250}. It is the most widely recognized side effect that carries a patient to a doctor's attention\unskip~\citep{963808:21049242}.  
    
\section{Materials and Methods}
Aceclofenacis gained as a gift example by Acesus Pharma, Ongole, Sodium starch glycolate, croscarmellose, methocel, Lubrizol, were obtained from Capricon, Hyderabad\unskip~\citep{963808:21049252}. All added substances of systematic grade are utilized.

\textbf{Calibration of Aceclofenac}

Aceclofenac standard resolution is organized by melting 10 mg of aceclofenac in a sufficient amount of ethanol and the volume was made with pH 7.5 phosphate buffers in a 10 mL volumetric flask. The standard answer is subsequently watery by the buffer to prepare 4, 8, 12, 16, and 20 \ensuremath{\mu}g/ml solution and the optical density is restrained at 273nm against a blank. Similarly, the calibration of aceclofenac was also performed in a pH of 1.2 buffers at 269nm.


\bgroup
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\centering \makeatletter\IfFileExists{images/cfb3fc64-bcd2-4a48-8114-9a632b1fdd2c-upicture1.png}{\includegraphics{images/cfb3fc64-bcd2-4a48-8114-9a632b1fdd2c-upicture1.png}}{}
\makeatother 
\caption{\boldmath {FTIR Spectra of (a) Aceclofenac and (b) Aceclofenac Bilayer }}
\label{f-7b3f1e2c1fb8}
\end{figure*}
\egroup
\textbf{Reformulation Studies}

Reformulation is designated as a phase of expansion-through that the physicochemical and biopharmaceutical belongings of a treatment material are considered. The drug was tested for organoleptic properties, solubility, and drug {\textendash} excipient compatibility studies\unskip~\citep{963808:21049247}. 

\textbf{Preparation of Aceclofenac bilayer tablets}

\textbf{Continued statement deposit of aceclofenac}

Physical mixtures of continued issue coating is organized by geometric dilution technique. Subsequently being grinded and examined, the drug is assorted by methocel and Lubrizol on the geometric basis in a mortar and pestle and the mixture was next approved over an 18-mesh screen to mix the constituents consistently and formerly assorted by talc and magnesium stearate for the subsequent tabletting procedure.

\textbf{Instantaneous statement layer of aceclofenac}

The physical mixture of the instantaneous issue layer was prepared by utilizing croscarmellose sodium and sodium starch glycolate by geometric dilution as per the comparable technique designated overhead.

\textbf{Research of bilayer tablets}

The bilayer tablets are fictional by 16 station rotary punch using 12mm punch via double compaction method. Briefly, the weighed physical mixture equivalent to 130 mg of aceclofenac of sustained released layer was fed manually into the die cavity and then compressed into tablets and sequentially the physical mixture equivalent to 70 mg of aceclofenac of instantaneous issue layer is fed into the same die cavity containing the sustained release tablet and was compressed. Table~\ref{tw-e65453605b5a} shows the complete arrangements verified by preparation of bilayer tablets.

\textbf{Precompressed properties}

The pre-compressed properties like the approach of rest, bulk density, tapped density, and compressibility index, to determine the flow properties of the prepared physical mixtures.

\textbf{Drug content}

The aceclofenac content was assayed separately for immediate release and sustained release physical mixtures. Physical mixture weighing 100mg of sustained as well as immediate-release was transferred and dissolved in 20 ml of ethanol further diluted with pH 7.5 phosphate buffer and make up the volume up to the mark with the buffer in a 100 ml volumetric flask individually. The answer was suitably diluted, and the aceclofenac content was restrained in contradiction of complete at 273nm by means of UV noticeable spectrophotometer.


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\centering \makeatletter\IfFileExists{images/2fdb72e1-917e-489c-a8cf-e1d038f05ff1-upicture2.png}{\includegraphics{images/2fdb72e1-917e-489c-a8cf-e1d038f05ff1-upicture2.png}}{}
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\caption{\boldmath {Comparative in-vitro dissolution profile of aceclofenac bilayer tablets}}
\label{f-196b60c467e5}
\end{figure}
\egroup

\begin{table*}[!htbp]
\caption{\boldmath {Formula of the aceclofenac bilayer tablets} }
\label{tw-e65453605b5a}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.15739999999999998\linewidth-2\tabcolsep}p{\dimexpr.11409999999999998\linewidth-2\tabcolsep}p{\dimexpr.0983\linewidth-2\tabcolsep}p{\dimexpr.0961\linewidth-2\tabcolsep}p{\dimexpr.11329999999999998\linewidth-2\tabcolsep}p{\dimexpr.11780000000000001\linewidth-2\tabcolsep}p{\dimexpr.1025\linewidth-2\tabcolsep}p{\dimexpr.08880000000000003\linewidth-2\tabcolsep}p{\dimexpr.1117\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}Formulation & ACF \mbox{}\protect\newline (mg) & SSG \mbox{}\protect\newline (mg) & CC \mbox{}\protect\newline (mg) & M K15M \mbox{}\protect\newline (mg) & L 971P \mbox{}\protect\newline (mg) & MS \mbox{}\protect\newline (mg) & Talc \mbox{}\protect\newline (mg) & MCC \mbox{}\protect\newline (mg)\\
\tblmidrule 
F1 &
  200 &
  5  &
  5  &
  5  &
  5  &
  5  &
  5  &
  250\\
F2 &
  200 &
  5  &
  5  &
  10 &
  10 &
  5  &
  5  &
  240\\
F3 &
  200 &
  10 &
  10 &
  20 &
  20 &
  5  &
  5  &
  210\\
F4 &
  200 &
  15 &
  15 &
  30 &
  30 &
  5  &
  5  &
  180\\
F5 &
  200 &
  20 &
  20 &
  40 &
  40 &
  5  &
  5  &
  150\\
F6 &
  200 &
  25 &
  25 &
  50 &
  50 &
  5  &
  5  &
  110\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Assessment parameters of Physical mixtures} }
\label{tw-c47a28303ee5}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.1702\linewidth-2\tabcolsep}p{\dimexpr.1498\linewidth-2\tabcolsep}p{\dimexpr.1503\linewidth-2\tabcolsep}p{\dimexpr.1545\linewidth-2\tabcolsep}p{\dimexpr.2139\linewidth-2\tabcolsep}p{\dimexpr.1613\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}Formulation & Angle of \mbox{}\protect\newline Repose & Bulk \mbox{}\protect\newline Density & Tapped \mbox{}\protect\newline Density & Compressibility \mbox{}\protect\newline Index & Drug \mbox{}\protect\newline Content\\
\tblmidrule 
F1 &
  32\ensuremath{\pm}0.2 &
  0.30\ensuremath{\pm}0.3 &
  0.31\ensuremath{\pm}0.2 &
  0.45\ensuremath{\pm}0.6 &
  98.13\ensuremath{\pm}0.8\\
F2 &
  28.2\ensuremath{\pm}1.8 &
  0.30\ensuremath{\pm}0.1 &
  0.33\ensuremath{\pm}0.2 &
  0.43\ensuremath{\pm}0.3 &
  100.1\ensuremath{\pm}1.2\\
F3 &
  32\ensuremath{\pm}0.5 &
  0.31\ensuremath{\pm}0.1 &
  0.33\ensuremath{\pm}0.2 &
  0.46\ensuremath{\pm}0.4 &
  99.5\ensuremath{\pm}1.6\\
F4 &
  31.4\ensuremath{\pm}0.2 &
  0.31\ensuremath{\pm}0.2 &
  0.33\ensuremath{\pm}0.2 &
  0.45\ensuremath{\pm}0.4 &
  97.5\ensuremath{\pm}1.4\\
F5 &
  31.8\ensuremath{\pm}0.4 &
  0.32\ensuremath{\pm}0.1 &
  0.33\ensuremath{\pm}0.1 &
  0.43\ensuremath{\pm}0.2 &
  101.5\ensuremath{\pm}1.2\\
F6 &
  32\ensuremath{\pm}0.2 &
  0.31\ensuremath{\pm}0.1 &
  0.32\ensuremath{\pm}0.3 &
  0.43\ensuremath{\pm}0.2 &
  101.13\ensuremath{\pm}1.2\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Evaluation Parameters of Aceclofeanc Bilayer Tablets} }
\label{tw-cc6b9c6db970}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.20580000000000002\linewidth-2\tabcolsep}p{\dimexpr.31139999999999997\linewidth-2\tabcolsep}p{\dimexpr.2162\linewidth-2\tabcolsep}p{\dimexpr.2666\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}Formulation & Weight Variation \% \mbox{}\protect\newline Error (n=3) & Friability & Drug Content \mbox{}\protect\newline (n=3)\\
\tblmidrule 
F1 &
  1.26\ensuremath{\pm}0.01 &
  0.8 &
  99.13\ensuremath{\pm}1.26\\
F2 &
  0.59\ensuremath{\pm}0.12 &
  0.6 &
  104.1\ensuremath{\pm}1.10\\
F3 &
  0.07\ensuremath{\pm}0.10 &
  0.1 &
  101.5\ensuremath{\pm}0.28\\
F4 &
  0.31\ensuremath{\pm}0.39 &
  0.1 &
  96.5\ensuremath{\pm}0.96\\
F5 &
  0.55\ensuremath{\pm}1.25 &
  0.3 &
  100.5\ensuremath{\pm}1.15\\
F6 &
  0.49\ensuremath{\pm}0.79 &
  0.1 &
  99.13\ensuremath{\pm}0.94\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}

\begin{table*}[!htbp]
\caption{\boldmath {Kinetic Data of Acecclofenac Bilayer Tablets} }
\label{tw-56f6e656a1ca}
\def\arraystretch{1.1}
\ignorespaces 
\centering 
\begin{tabulary}{\linewidth}{p{\dimexpr.19759999999999998\linewidth-2\tabcolsep}p{\dimexpr.0955\linewidth-2\tabcolsep}p{\dimexpr.09759999999999998\linewidth-2\tabcolsep}p{\dimexpr.09990000000000002\linewidth-2\tabcolsep}p{\dimexpr.11940000000000001\linewidth-2\tabcolsep}p{\dimexpr.10280000000000001\linewidth-2\tabcolsep}p{\dimexpr.1135\linewidth-2\tabcolsep}p{\dimexpr.0906\linewidth-2\tabcolsep}p{\dimexpr.0831\linewidth-2\tabcolsep}}
\tbltoprule \rowcolor{kwdboxcolor}Formulation & \multicolumn{2}{p{\dimexpr(.1931\linewidth-2\tabcolsep)}}{\cAlignHack Zero-order} & \multicolumn{2}{p{\dimexpr(.21930000000000003\linewidth-2\tabcolsep)}}{\cAlignHack First-order} & \multicolumn{2}{p{\dimexpr(.21630000000000003\linewidth-2\tabcolsep)}}{\cAlignHack Higuchi} & \multicolumn{2}{p{\dimexpr(.1737\linewidth-2\tabcolsep)}}{\cAlignHack Korse Meyer}\\
\rowcolor{kwdboxcolor} & K\ensuremath{_{0}} & R\ensuremath{^{2}} & K\ensuremath{_{1}} & R\ensuremath{^{2}} & K\ensuremath{_{H}} & R\ensuremath{^{2}} & K\ensuremath{_{K}} & R\ensuremath{^{2}}\\
\tblmidrule 
F1 &
  13.49 &
  0.869 &
  0.484 &
  0.860 &
  64.147 &
  0.879 &
  0.240 &
  0.246\\
F2 &
  19.077 &
  0.794 &
  0.451 &
  0.980 &
  45.4 &
  0.921 &
  0.914 &
  0.566\\
F3 &
  7.51 &
  0.648 &
  0.194 &
  0.843 &
  28.52 &
  0.973 &
  0.678 &
  0.306\\
F4 &
  5.052 &
  0.753 &
  0.105 &
  0.274 &
  19.494 &
  0.923 &
  0.519 &
  0.254\\
F5 &
  4.10 &
  0.877 &
  0.150 &
  0.712 &
  17.691 &
  0.972 &
  0.854 &
  0.628\\
F6 &
  2.34 &
  0.878 &
  0.099 &
  0.781 &
  11.149 &
  0.901 &
  0.545 &
  0.409\\
\tblbottomrule 
\end{tabulary}\par 
\end{table*}
\textbf{Evaluation of Bilayer Tablets}

\textbf{Weight variety}

Weight variety might have been computed as for every those technique portrayed for USP. Twenty tablets were chosen haphazardly, and What's more, their Normal weight might have been controlled utilizing an electronic equalization. Those tablets were weighed separately. What's more compared with Normal weight 13.

\textbf{Friability}

Friability might have been controlled utilizing Roche friabilator Furthermore computed Likewise for every those technique depicted Previously, USP. Twenty tablets were weighed and put in the tumbling chamber Furthermore turned In 25 rpm to 5 min. Tablets were weighed once more and the rate weight reduction might have been dead set utilizing those recipe provided for below 8.

$\%\;friability=beginning\;weight-last\;weight\;\ast\;100/introductory\;weight. $

\textbf{Drug content}

Those tablets might have been taken clinched alongside An 100ml volumetric flask, 20ml ethanol and 20ml about ph 7. 5 phosphate support were included and the substance was sonicated to 10 min Also constructed up to those Stamp with ph 7. 5 phosphate support. The result might have been bag weakened with ph 7. 5 phosphate cushion and might have been assayed toward 273nm to aceclofenac.

\textbf{In-vitro disintegration investigations}

That disintegration rate testing from claiming aceclofenac bilayered tablets (table) might have been examined utilizing USP kind I~rate testing mechanical assembly (basket type) turned during 50rpm. Those disintegrations might have been performed with 900mL for ph 1. 2 support up to 2 hours et cetera swapped with 900 ml ph 7. 5, 0. 3M phosphate cushion toward 37. 0 \ensuremath{\pm} 0. 5 0C. Toward particular the long run intervals, a 5 ml aliquot of the broken-down medium might have been withdrawn. What's more, might have been swapped with a new amount from claiming disintegration medium. Those tests were bag weakened with disintegration medium Furthermore assayed to aceclofenac content by measuring that absorbance during 269 What's more 273 nm separately for pH1. 2 Furthermore pH7. 5 buffers utilizing u. V spectrophotometer (ELICO sl 159). The effects need aid provided for in the table. Those investigations were conveyed to triplicate. 
    
\section{Results and Discussion}
The bilayer tablets that are prepared by double compaction technique were used to attain faster onset of action by the loading dose incorporated in the immediate release layer followed by supporting the action of aceclofenac from the sustained layer for a prolonged effect. Moreover, methocel K15M and Lubrizol 971P were used as sustaining agents; CCS and SSG were used as super disintegrants for the immediate release of aceclofenac.

\textbf{Evaluation of Physical Mixtures}

\textbf{FTIR studies}

The physical mixtures were characterized by FTIR to determine the compatibility between the aceclofenac and the excipients used. The FTIR spectra of pure aceclofenac presented distinguishing peaks at 3444.6 cm\ensuremath{^{-1}}, 2919.50 cm\ensuremath{^{-1}}, 1505.65 cm\ensuremath{^{-1}}, and 777.36 cm\ensuremath{^{-1}} due to N-H stretching, C-H stretching, -C=C, and aromatic-Cl correspondingly. The FTIR spectra of the bilayer tablet (F6) exhibited similar characteristic peaks as similar to the pure aceclofenac indicating that there was not any drug and excipient incompatibility in the designed formulation. The FTIR spectra are revealed in Figure~\ref{f-7b3f1e2c1fb8}.

\textbf{Pre compressed Properties}

Before compression, the physical mixtures were evaluated for flow properties for better compaction by the results it is experimental that the physical mixture of preparation F6 showed 30.73\ensuremath{\pm}1.23, 0.30\ensuremath{\pm}0.28, 0.32\ensuremath{\pm}0.11, and 0.45\ensuremath{\pm}0.10 of the angle of relaxation, bulk density, tapped density and squeezability index respectively indicating an excellent flow indices which may be due to the uniform distribution of all excipients in physical mixtures and a uniform particle size due to the uniform distribution of particles revealing the efficiency of geometric dilution method used for the preparation of physical mixtures. The data was shown.

\textbf{Drug content}

The physical mixtures used for the preparation of the immediate layer and sustained layer of bilayer tablets were assayed separately for aceclofenac content. From the results, it is observed that the drug content was within the limits of 95 {\textendash} 100\% for together instant and sustained statement layers. The data is shown.

\textbf{Evaluation of Bilayer Tablets}

\textbf{Weight Variation}

Weight variation is approved out to guarantee that, every tablet containing a specified quantity of the drug. From the results, it is observed that the determined weight difference obtained is \ensuremath{\pm}0.52, that falls inside the satisfactory weight difference variety of \ensuremath{\pm}5\%. 

From now, all the tablets approved the weight difference test. The results were shown in Table~\ref{tw-c47a28303ee5}.

\textbf{Friability}

The physical strength of tablets upon exposure to mechanical shock and attrition was measured by the friability test apparatus. From the results, it is observed that the tablets had not shown a notable effect on the friability of aceclofenac tablets which may be due to the lower quantity of magnesium stearate in the preparation. The results were shown.

\textbf{Drug Content}

The quantity of aceclofenac in the bilayer tablet was assayed to know the amount of the drug in the amount form. The results indicated that all the formulations exhibited 99-100\% of aceclofenac in the dosage forms indicating that the exact amount of immediate-release layer and sustain layer was taken by the research of bilayer tablets. The consequences are shown.

\textbf{In-vitro Dissolution Studies}

In the current investigation, aceclofenac issue by bilayer tablets is evaluated utilizing USP Type-II closure rate testing gadget. 900mL of pH 1.2 buffers was selected as a dissolution medium for the first two hours, followed by pH7.5 phosphate buffer. The effect of various polymers like L971P and MK15m was studied. The comparative drug issue outlines of bilayer tablets were exposed in Figure~\ref{f-196b60c467e5}. 

The drug was released rapidly from F1 and F2 within 1hr and 4hrs respectively, but the formulations F3 and F4 showed slow release and lasted for 6hrs and 9hrs respectively. Whereas, the release of aceclofenac from formulations F5 and F6 was much slower and sustained up to 11hrs and 12hrs respectively. 

From the results, it is experimented by increasing in the attention of SSG and CCS enhanced the release of aceclofenac from the immediate release of bilayer tablets about 86.78\% within 5 min indicating a burst release of initial dose for faster onset of action.

The increase in the concentration of L971P and MK15M slowed the release of aceclofenac from the sustained layer, and the complete release of aceclofenac was observed at 12hrs sustaining the action for a longer period. The sustained effect of aceclofenac in F6 is due to the swelling property of the MK15M and L971P and erosion, so the formulation sustains the drug release to extended time points. 

To improved understand the announcement profiles gotten by aceclofenac bilayer tablets, the drug release data gotten at dissimilar time points were fitted into kinetic models like zero order, and first-order, to appreciate the apparatus of drug release by bilayer tablet the information was tailored to Korsmeyer Peppas model and was shown in Table~\ref{tw-cc6b9c6db970}.  

From the results it is noticed that the K values are less for the formulation F6 compared to other formulation K values of all the kinetic models making a note that the release rate was decreasing from the dosage form due to increase in the concentration of MK15M and L971P, the correlation coefficient values are high for Higuchi model compared to other kinetic models ranging about0.879-0.973representing that diffusion as the mechanism of drug release by bilayer tablet in Table~\ref{tw-56f6e656a1ca}.
    
\section{Conclusions}
Aceclofenac bilayer tablets were successfully prepared by double compaction of immediate announcement layer and continued layer physical mixtures which are ready by geometric dilution technique. The polymers MK15M and L971P showed a sustained effect for about 12 hrs and the super disintegrants in the immediate release layer produced an initial burst release and found to be giving effective and safe dissolution profile for 12 hours.

\textbf{Conflict of interest}

The authors declare that they have no conflict of interest for this study.

\textbf{Funding support}

The authors declare that they have no funding support for this study.
    

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