A Study of Correlation of Serum Uric Acid Levels With Diabetic Complications

Abstract

Diabetes is the leading cause of adult blindness, end stage renal disease, coronary heart disease, stroke, foot ulcers and lower limb amputations. Serum uric acid levels independently predict the development of macro vascular and micro vascular complications. In this study we analyse the association of serum uric acid with the macro and micro vascular complications of diabetes. In this hospital based observational study, hundred diabetic patients were included; of which fifty had complications, the remaining fifty had no complications. Blood investigations including fasting and post prandial blood sugars, glycosylated haemoglobin, serum creatinine, micro albuminuria, lipid profile, serum uric acid were done in all patients. All the parameters were compared between the two groups. Males with complications had significant high uric acid than females with complications. HbA1c, total cholesterol levels, micro albuminuria, serum creatinine had a positive correlation with the serum uric acid. Uric acid levels were higher among patients with complications compared to patients without complications which was statistically significant (p =0.00001). Patients with nephropathy, retinopathy and coronary heart disease had elevation in serum uric acid levels which was statistically significant. Patients with complications had higher uric acid levels than patients without complications.