A Study on Extraction and Characterization of Vigna mungo Polymer

Krishnaveni Manubolu (1) , Sreenivasulu Munna (2) , Chandrasekhar Kothapalli Bonnoth (3)
(1) Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu-515002, Andhra Pradesh, India, India ,
(2) Department of Pharmaceutical Chemistry, Santhiram College of Pharmacy, Nandyal, Kurnool- 518501, Andhra Pradesh, India, India ,
(3) Department of Chemistry, Krishna University, Machilipatnam, Krishna- 521001, Andhra Pradesh, India, India

Abstract

The aim of work is to extract and characterize the Vigna mungo polymer solvent using acetone and ethanol. Natural polymers contribution towards formulation of dosage forms is appreciable as they are biocompatible, biodegradable and safe. So extraction and characterization of Vigna mungo polymer helps in the interaction studies of preformulation. In this present study, various physicochemical characters like phytochemical screening, viscosity, particle size analysis, and flow characteristics were determined. Further characterization performed using FTIR and XRD. Vigna mungo polymer obtained using acetone was taken into further studies of evaluation because of more product yield and less particle size. FTIR results revealed existence of carbohydrate nature. X-ray diffractogram presented degree of crystallinity 26.4%. And phytochemical screening of the extracted polymer indicated presence of mucilage and carbohydrates using ruthenium red and molisch's test. Statistical analysis of data was performed using two way ANOVA using Graphpad prism 5 software was used to compare Vigna mungo polymer extracted using acetone and ethanol. Physicochemical parameters experimental data found to be statistical significance two way ANOVA (P < 0.05).

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References

Auwal, M. S., Saka, S., Mairiga, I. A., Sanda, K. A., Shuaibu, A., Ibrahim, A. 2014. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). Veterinary research forum: an international quarterly journal 2014, 5(2):95.

Avachat, A. M., Gujar, K. N., Wagh, K. V. 2013. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydrate Polymers, 91(2):537–542.

Bhatta, R., Hossain, M. S., Banik, S., Moghal, M. M. R. 2018. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. Marmara Pharmaceutical Journal, 22(2):286–298.

Deshmukh, S. S., Katare, Y. S., Shyale, S. S., Bhujbal, S. S., Kadam, S. D., Landge, D. A., Shah, D. V., Pawar, J. B. 2013. Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent. Journal of Pharmaceutics, 2013:1–4.

Evans, W. C. 2009. Trease and evans’ pharmacognosy E-book. page 616. Elsevier Health Sciences, 16th edition.

Figueiró, S. D., Góes, J. C., Moreira, R. A., Sombra, A. S. B. 2004. On the physico-chemical and dielectric properties of glutaraldehyde crosslinked galactomannan–collagen films. Carbohydrate Polymers, 56(3):313–320.

Harborne, A. J. 1998. Phytochemical methods a guide to modern techniques of plant analysis. page 302. Springer science & business media.

Jani, G. K., Shah, D. P., Prajapati, V. D., Jain, V. C. 2009. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci, 4(5):309–323.

Joshi, J. R., Patel, R. P. 2012. Role of biodegradable polymers in drug delivery. Int J Curr Pharm Res, 4(4):74–81.

Layek, B., Mandal, S. 2020. Natural polysaccharides for controlled delivery of oral therapeutics: a recent update. Carbohydrate Polymers, 230:115617.

Liechty, W. B., Kryscio, D. R., Slaughter, B. V., Peppas, N. A. 2010. Polymers for Drug Delivery Systems. Annual Review of Chemical and Biomolecular Engineering, 1(1):149–173.

Parida, P., Mishra, S. C., Sahoo, S., Behera, A., Nayak, B. P. 2016. Development and characterization of ethylcellulose based microsphere for sustained release of nifedipine. Journal of Pharmaceutical Analysis, 6(5):341–344.

Pawar, H. A., Lalitha, K. G. 2015. Extraction, Characterization, and Molecular Weight Determination of Senna tora (L.) Seed Polysaccharide. International Journal of Biomaterials, 2015:1–6.

Peng, Y., Zhang, L., Zeng, F., Xu, Y. 2003. Structure and antitumor activity of extracellular polysaccharides from mycelium. Carbohydrate Polymers, 54(3):297–303.

Prado, B. M., Kim, S., Özen, B. F., Mauer, L. J. 2005. Differentiation of Carbohydrate Gums and Mixtures Using Fourier Transform Infrared Spectroscopy and Chemometrics. Journal of Agricultural and Food Chemistry, 53(8):2823–2829.

Prashanth, M. R. S., Parvathy, K. S., Susheelamma, N. S., Prashanth, K. V. H., Tharanathan, R. N., Cha, A., Anilkumar, G. 2006. Galactomannan esters—A simple, cost-effective method of preparation and characterization. Food Hydrocolloids, 20(8):1198–1205.

Satturwar, P. M., Fulzele, S. V., Dorle, A. K. 2003. Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer. AAPS PharmSciTech, 4(4):434–439.

Senguttuvan, J., Paulsamy, S., Karthika, K. 2014. Phytochemical analysis and evaluation of leaf and root parts of the medicinal herb, Hypochaeris radicata L. for in vitro antioxidant activities. Asian Pacific Journal of Tropical Biomedicine, 4:S359–S367.

Senthil, V., Sripreethi, D. 2011. Formulation and evaluation of paracetamol suspension from Trigonella foenum graecum mucilage. Journal of advanced pharmacy education and research, 1(5):225–233.

Shah, B. N. 2009. Textbook of pharmacognosy and phytochemistry. page 586. Elsevier India. Elsevier India.

Singh, S., Bothara, S. B. 2014. Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb. Brazilian Journal of Pharmaceutical Sciences, 50(4):713–725.

Soni, A., Gupta, O., Verma, H. K., Chaudhary, A. 2019. Isolation and Characterization of Binding agent from Black Gram. Asian Journal of Pharmacy and Technology, 9(3):189–194.

Tiwari, P., Panthari, P., Katare, D. P., Kharkwal, H. 2014. Natural polymers in drug delivery. World J. Pharm. Pharm. Sci, 3(9):1395–1409.

Vishakha, S. K., Kishor, D. B., Sudha, S. 2012. Natural polymers-A comprehensive review. International journal of research in pharmaceutical and biomedical sciences, 3(4):1597–1613.

Yadav, I. K., Durga, J., Singh, H. P., Dinesh, C., Jain, D. A. 2009. Evaluation of seed mucilage of Vigna mungo (L.) as a binder in tablet formulations. Journal of Pharmacy Research, 2(8):1281–1282.

Yuen, S. N., Choi, S. M., Phillips, D. L., Ma, C. Y. 2009. Raman and FTIR spectroscopic study of carboxymethylated non-starch polysaccharides. Food Chemistry, 114(3):1091–1098.

Zhang, L., Yang, Q., Ding, X., Chen 1995. Studies on molecular weights of polysaccharides of Auricularia auricula-judae. Carbohydrate Research, 270(1):1–10.

Authors

Krishnaveni Manubolu
krishnaveni.manubolu@gmail.com (Primary Contact)
Sreenivasulu Munna
Chandrasekhar Kothapalli Bonnoth
Krishnaveni Manubolu, Sreenivasulu Munna, & Chandrasekhar Kothapalli Bonnoth. (2021). A Study on Extraction and Characterization of Vigna mungo Polymer. International Journal of Research in Pharmaceutical Sciences, 12(3), 1870–1878. Retrieved from https://ijrps.com/home/article/view/117

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