Association of ABO and RH Blood Groups with Diabetes
Abstract
Diabetes mellitus (DM) expresses a so-called metabolic abnormality resulting from a defect in the secretion of insulin secreted by the pancreas, and this causes a metabolic disorder, i.e. the metabolic syndrome of both triglycerides and carbohydrates, which in turn leads to high blood sugar as well. DM consists of two types, one insulin-dependent and the other non-insulin-dependent. In the past years, researchers have found a relationship between each of the ABO blood groups with susceptibility to certain diseases, as it was found that peptic ulcer disease is most affected by people with blood type O. The vast majority of them suffer from stomach cancer in addition to increased susceptibility to sweating. In our current research, our study includes DM metabolic disorder and its relationship to each of the different blood groups of people as well as the ABO/Rhesus (Rh.) factor.
Keywords
Mellitus (DM), ABO Blood Group, Rhesus Factor (Rh)
Introduction
ABO blood types, in their various forms, are inherited and are opposite, as they are located on the surface of both red blood cells and other tissues (Siransy, Nanga, Zaba, & Tufa, 2015). Blood type is a term describing antigens of the red blood cells (RBCs) controlled by gene chains closely related to the antigens of the chromosomes. The basis of the difference in blood groups results from the difference in each of their components of protein and carbohydrates (Mitra, Mishra, & Rath, 2014).
Blood group antigens are hereditary determined and Play a vital role in transfusion safety, understanding genetics, inheritance pattem, and disease susceptibility (Huston, Aunar, & Graham, 2002). Rhesus factor (Rh) is the most prevalent blood group after ABO, possibly due to the theatrical presentation of hemolytic fetal hemolytic disease (HDN) after allogeneic immunization of self to antigen (Murphy & Roberts, 2017). There are 49 antigens for the Rh blood group. There are 49 antigens for the Rh blood group of which type, DC ... E and e, and Rh is one of the most common (D) and it is of two types, positive or negative. While there are more than 36 different ABO blood type systems consisting of more than 379 antigens listed by the International Society of Blood Transfusion, where ABO is the most studied group among humans (Davison & Hendrickse, 2020).
|
Blood group |
Studied groups |
||
|---|---|---|---|
|
Type1DM(104) |
Type2DM(123) |
Compact(195) |
|
|
A |
22(21.1%) |
31(25.2%) |
45(23.8%) |
|
B |
27(25.9%) |
23(17.6%) |
62(31.8%) |
|
AB |
5(4.8%) |
10(8.1%) |
20(10.2%) |
|
O |
50(48%) |
59(47.9%) |
68(34.8%) |
|
Blood group |
Studied groups |
||
|---|---|---|---|
|
Type1DM(104) |
Type2DM(123) |
Compact(195) |
|
|
RH+ |
79(93.2%) |
114(92.6%) |
168(86.1%) |
|
RH- |
7(6.1%) |
97(7.3%) |
27(11.3%) |
There are variations between ABO blood types with increased susceptibility to sweating, for example. Studies have shown that people with blood type A are more likely to get stomach cancer, while stomach and duodenal ulcers occur more commonly among blood type members (Sharma, Sharma, & Tyler, 2011). Some epidemiological studies have shown a significant association between the ABO blood group and diabetes. In the study of Barbaric et al., it was reported that blood group B was associated with a lower risk of diabetes compared with blood group 0. On the other hand, Fagherazzi et al., blood type 0 as a protective agent against type 2 DM (Huang, Yoo, & Choi, 2008). The current study aims to determine the relationship between ABO blood groups, Rh factor and diabetes mellitus in Iraq.
Methods
Blood samples were obtained from the vein using a syringe with (1-20) ml and a volume of (1-20) ml. The distribution/blood type ABO/Rh blood was obtained from 227 diabetic patients at the Special Center for Endocrinology and Diabetes in Rusafa/Baghdad. The samples were chosen at random. One hundred and four Type 1 DMs and one hundred and twenty-three Type 2 DMs were among them (Kashfi, Jeihooni, & Afshariani, 2010).
Results and Discussions
One hundred and twenty-three were Type 2 DMs. However, the most important condition of the research was to focus on the blood sugar level to be 126 mg/decilitre (7.0 mmol./L) for people taking treatment. As for people who did not take treatment for diabetes, their blood sugar level must not be less than 110 mg/dL (6.1 mmol/L). ABO blood group test was performed by agglutination of slides (Barbalic & Dupuis, 2010).
Blood type Was associated with a high proportion of both type 1 and type 2 blood type AB diabetes has a minimum associated with each type 1 and type 2 DM (Fagherazzi & Gusto, 2010). The blood group was almost equally unreliable in both diabetic and non-diabetic patients (Table 1). Also, RH+ve is significantly more in both diabetic and control patients than RH-ve in our population (Table 2).
Conclusions
Through the results of the research, it was found that blood type O is more likely to develop D.M for people who carry it compared to people who carry blood type AB. It is necessary to increase the attention and care of people with blood types.
Acknowledgement
The researcher is very thankful to the Specialized Center for Endocrinology and Diabetes.
Funding Support
The authors declare that they have no funding support for this study.
Conflict of Interest
The authors declare that there is no conflict of interest.